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Answer :
- Compression force
- Binder quantity (More binder more hardness)
- Moisture content
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Answer :Chewable Tablets
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Answer :Capping: ‘Capping’ is the term used, when the upper or lower segment of the tablet separates horizontally, either partially or completely from the main body of a tablet and comes off as a cap, during ejection from the tablet press, or during subsequent handling.Lamination / Laminating: ‘Lamination’ is the separation of a tablet into two or more distinct horizontal layers.Sticking/filming: ‘Sticking’ refers to the tablet material adhering to the die wall. Filming is a slow form of sticking and is largely due to excess moisture in the granulation.Cracking: Small fine cracks observed on the upper and lower center surface of the tablets, or very rarely on the side wall are referred to as cracks.Chipping: ‘Chipping’ is defined as the breaking of tablet edges, while the tablet leaves the press or during subsequent handling and coating operation.Mottling: ‘Mottling’ is the term used to describe an unequal distribution of color on a tablet.Double Impression: ‘Double impression’ involves only those punches, which have a monogram or other engraving on them.
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Answer :15 - 250 C & 35 -55% RH
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Answer :
- If the granules are not dried properly sticking can occur.
- Too little or improper lubrication.
- Too much binder
- Hygroscopic granular
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Answer :In tablet manufacturing facilities, pressure gradients are maintained to avoid cross contamination of products through air. Usually processing areas are maintained under positive pressure with respect to service corridors.
Answer :
In an elixir, the active ingredients are mixed with a liquid, usually a kind of syrup or alcohol, in which they can dissolve.
In a suspension, the medicine is mixed with a liquid, usually water, in which it cannot dissolve and therefore remains intact in the form of small particles. The important thing to remember is that you have to shake a suspension before giving each dose so that the medicine particles are evenly distributed throughout the liquid.
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Answer :
Design Qualification (DQ):documented verification that the proposed design of the facilities, equipment, or systems is suitable for the intended purpose.
Installation Qualification (IQ):documented verification that the equipment or systems are installed or modified & comply with the approved design of the manufacturer’s recommendations and/or user requirements.
Operational Qualification (OQ):documented verification that the equipment or systems are installed or modified & perform as intended throughout the anticipated operating ranges.
Performance Qualification (PQ):documented verification that the equipment and ancillary systems are connected & can perform effectively and reproducibly based on the approved process method and specifications.
Answer :
Heating, Ventilating and Air conditioning system is used for temperature and humidity control within a manufacturing environment. It includes air handling units, air distribution network, air-cooling and heating system, air filtration, equipment control system, monitoring and alarm decreases
Answer :
Clean Room: A room in which the concentration of airborne particles is controlled to meet specified airborne particulate cleanliness class. In addition, the concentration of microorganisms in the environment is monitored; is cleanliness class defined is also assigned a microbial level for air, surface, and personnel gear.
Aseptic Area: Any area in an aseptic process system for which airborne particulate and microorganism levels are controlled to specific levels appropriate to the activities conducted within that environment.
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Answer :
Water for Injection (Bulk)-
Characters-A clear, colorless, odorless and tasteless liquid.
- Nitrates-Not more than 0.2 ppm
- Heavy metals-Not more than 0.1 ppm
- Conductivity-Conductivity at 20°C not more than 1.1 µS.cm-1.
- Microbial Contamination-Total viable aerobic count should less than 10 micro-organism per 100 ml. Absence of E.
- Coli, Salmonella, Staphylococcus aureus & Pseudomonas.
- Bacterial endotoxins-Less than 0.25 IU per ml.
Answer :
- Propellant
- Container
- Valve and actuator
- Product concentrate
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Answer :solute = 4000x = 200 gS g. = 100 ml ,X = 4000 mlX = 4000 x S/100 = 200 g
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Answer :Volume in ml = 75/0.1 =750 ml
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Answer :
- An ointment is 80 percent oil and 20 percent water.
- A cream is 50 percent oil and 50 percent water.
- Ointment is an emulsion of water/Oil
- A cream is an emulsion of Oil/water, Thick
- Thin Ointment has very moisturizing effect, Preferable for Dry skin
- Cream has moderate in moisturizing. Preferable for moist skin
Answer :
In fluid dynamics, a vortex is a region within a fluid where the flow is mostly a spinning motion about an imaginary axis, straight or curved.
Answer :
- Wet granulation
- Dry granulation
- Direct compression
Answer :
- Physical Method
- Thermal (Heat) methods
- Radiation method
- Filtration method
- Chemical Method
- Gaseous method
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Answer :BFS means Blow Fill Seal. This technology usually used for sterilized product like ophthalmic drops, where container preparation, material fill and sealing all are happen at a time.
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Answer :The effervescent tablet mainly consists of three components:
- Active ingredient
- Acid source
- Alkaline compound, constituted by a carbonate or bicarbonate
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